The research, conducted in the labs of Joshua Sanes and Jeff Lichtman and described this week in the journal Proceedings of the National Academy of Sciences, begins to explain prior findings that exercise and restricted-calorie diets help to stave off the mental and physical degeneration of aging.

“Caloric restriction and exercise have numerous, dramatic effects on our mental acuity and motor ability,” says Sanes, a professor of molecular and cellular biology and director of the Center for Brain Science at Harvard.

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